Regulation of context-specific gene expression by posttranscriptional switches

Transcription. 2013 Sep-Dec;4(5):213-6. doi: 10.4161/trns.26393.

Abstract

Post-transcriptional control of mRNA is a vital step in the regulation of gene expression. Highly specific combinations of RNA-binding–proteins (RBPs) and microRNAs conjointly contribute to the complexity of post-transcriptional control of mRNAs. Post-transcriptional switches regulated by RBPs control context-specific expression of two alternative gene products from a single transcript.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease
  • Exons / genetics
  • Gene Expression Regulation*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Wound Healing / genetics

Substances

  • MicroRNAs
  • RNA, Messenger
  • RNA-Binding Proteins