Pallidotomy after chronic deep brain stimulation

Neurosurg Focus. 2013 Nov;35(5):E5. doi: 10.3171/2013.8.FOCUS13293.

Abstract

Recent publications have demonstrated that deep brain stimulation for Parkinson's disease still exerts beneficial effects on tremor, rigidity, and bradykinesia for up to 10 years after implantation of the stimulator. However with the progression of Parkinson's disease, features such as cognitive decline or "freezing" become prominent, and the presence of an implanted and functioning deep brain stimulator can impose a profound burden of care on the clinical team and family. The authors describe their experience in treating 4 patients who underwent removal of the implanted device due to either progressive dementia requiring full-time nursing or due to infection, and who subsequently underwent a unilateral pallidotomy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Antiparkinson Agents / therapeutic use
  • Cognition Disorders / etiology
  • Combined Modality Therapy
  • Deep Brain Stimulation*
  • Device Removal
  • Disease Progression
  • Electrodes, Implanted / adverse effects
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pallidotomy*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / psychology
  • Parkinson Disease / surgery
  • Parkinson Disease / therapy*
  • Quality of Life
  • Retrospective Studies
  • Salvage Therapy*
  • Treatment Outcome
  • Wound Infection / drug therapy
  • Wound Infection / etiology

Substances

  • Anti-Bacterial Agents
  • Antiparkinson Agents