Abstract
Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. The application of the principles of synthetic biology to enhance T cell function has resulted in substantial increases in clinical efficacy. The primary challenge to the field is to identify tumor-specific targets to avoid off-tumor, on-target toxicity. Given recent advances in efficacy in numerous pilot trials, the next steps in clinical development will require multicenter trials to establish adoptive immunotherapy as a mainstream technology.
MeSH terms
-
Adoptive Transfer
-
Animals
-
Antigens / genetics
-
Antigens / immunology
-
Biomarkers
-
Cell- and Tissue-Based Therapy
-
Gene Transfer Techniques
-
Genetic Therapy
-
Humans
-
Immunotherapy, Adoptive*
-
Neoplasms / genetics
-
Neoplasms / immunology*
-
Neoplasms / therapy*
-
Receptors, Antigen, T-Cell / immunology
-
Receptors, Antigen, T-Cell / metabolism
-
T-Cell Antigen Receptor Specificity / immunology
-
T-Lymphocyte Subsets / cytology
-
T-Lymphocyte Subsets / immunology
-
T-Lymphocyte Subsets / metabolism
-
Transduction, Genetic
-
Virus Diseases / genetics
-
Virus Diseases / immunology*
-
Virus Diseases / therapy*
Substances
-
Antigens
-
Biomarkers
-
Receptors, Antigen, T-Cell