Amyloid-Beta related angiitis of the central nervous system: case report and topic review

Amre Nouh; Ewa Borys; Angelica K Gierut; José Biller

doi:10.3389/fneur.2014.00013

Amyloid-Beta related angiitis of the central nervous system: case report and topic review

Front Neurol. 2014 Feb 4:5:13. doi: 10.3389/fneur.2014.00013. eCollection 2014.

Authors

Amre Nouh¹, Ewa Borys², Angelica K Gierut³, José Biller¹

Affiliations

¹ Department of Neurology, Stritch School of Medicine, Loyola University Chicago , Maywood, IL , USA.
² Section of Neuropathology, Department of Pathology, Stritch School of Medicine, Loyola University Chicago , Maywood, IL , USA.
³ Section of Allergy, Immunology and Rheumatology, Stritch School of Medicine, Loyola University Chicago , Maywood, IL , USA.

Abstract

Amyloid-beta related angiitis (ABRA) of the central nervous system (CNS) is a rare disorder with overlapping features of primary angiitis of the CNS and cerebral amyloid angiopathy. We evaluated a 74-year-old man with intermittent left sided weakness and MRI findings of leptomeningeal enhancement, vasogenic edema, and subcortical white matter disease proven to have ABRA. We discuss clinicopathological features and review the topic of ABRA.

Keywords: amyloid-beta related angiitis; cerebral amyloid angiopathy; cerebral amyloid angiopathy-related inflammation; leptomeningeal enhancement; primary angiitis of the central nervous system.