Abstract
Dextran modified with pendant acetals is used to load doxorubicin (DOX) and a near-infrared-emissive conjugated polymer (BTTPF), and this aims to provide selective drug release at therapeutic targets including tumors. The BTTPF is applicable to tracking the anticancer drug release through the change of Förster resonance energy transfer efficiency between doxorubicin and BTTPF during degradation of the nanoparticles in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Doxorubicin / administration & dosage
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Doxorubicin / analysis*
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Doxorubicin / pharmacokinetics
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Drug Delivery Systems / methods*
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Fluorescence Resonance Energy Transfer / methods*
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Fluorescent Dyes / administration & dosage
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Fluorescent Dyes / analysis*
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Fluorescent Dyes / pharmacokinetics
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Hydrogen-Ion Concentration
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Mice
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Nanoparticles / administration & dosage
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Nanoparticles / analysis*
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Nanoparticles / metabolism
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Polymers / administration & dosage
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Polymers / analysis
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Polymers / pharmacokinetics
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Spectroscopy, Near-Infrared / methods*
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Xenograft Model Antitumor Assays / methods
Substances
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Fluorescent Dyes
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Polymers
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Doxorubicin