Abstract
Importance:
Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic basis.
Observations:
In this case report, we describe a patient with NMOSD whose test results were seropositive for aquaporin-4 IgG and who had a hepatic metastasis from a small-bowel neuroendocrine tumor. The tumor cells expressed aquaporin-4 immunoreactivity. She presented to the Neurology Department at Wayne State University with bilateral leg weakness, ascending paresthesias, and decreased sensation.
Conclusions and relevance:
This case extends the context of NMOSD as a paraneoplastic disorder.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aquaporin 4 / biosynthesis
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Aquaporin 4 / genetics*
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Carcinoid Tumor / complications
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Carcinoid Tumor / diagnosis
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Carcinoid Tumor / genetics*
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Female
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Gene Expression Regulation / immunology
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Humans
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Intestinal Neoplasms / diagnosis
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Intestinal Neoplasms / genetics*
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Intestinal Neoplasms / immunology
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Liver Neoplasms / diagnosis
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Liver Neoplasms / genetics*
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Liver Neoplasms / secondary
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Middle Aged
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Neuromyelitis Optica / diagnosis
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Neuromyelitis Optica / genetics*
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Neuromyelitis Optica / immunology
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Paraneoplastic Syndromes, Nervous System / diagnosis
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Paraneoplastic Syndromes, Nervous System / genetics*
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Paraneoplastic Syndromes, Nervous System / immunology
Substances
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AQP4 protein, human
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Aquaporin 4