Abstract
Hyphenrones A-F (1-6), six polycyclic polyprenylated acylphloroglucinol derivatives with four architectures including three unprecedented cores as exemplified by 1, 3, and 4, were isolated from Hypericum henryi. Compounds 3 and 4 possess two unique 5/8/5 and 6/6/5/8/5 fused ring systems, respectively. Their absolute configurations were defined by experimental and calculated ECD of 4 and X-ray diffractions of 5 and 6, coupled with their putative biosynthetic origins. Three compounds exhibited interesting AChE inhibitory activities.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Cholinesterase Inhibitors / chemistry*
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Cholinesterase Inhibitors / isolation & purification
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Cholinesterase Inhibitors / pharmacology
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HL-60 Cells
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Humans
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Hypericum / chemistry*
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Molecular Structure
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Phloroglucinol / analogs & derivatives
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Phloroglucinol / chemistry*
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Phloroglucinol / isolation & purification
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Phloroglucinol / pharmacology
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Polycyclic Compounds / chemistry*
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Polycyclic Compounds / isolation & purification
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Polycyclic Compounds / pharmacology
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X-Ray Diffraction
Substances
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Antineoplastic Agents, Phytogenic
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Cholinesterase Inhibitors
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Polycyclic Compounds
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Phloroglucinol