Abstract
Intravenous administration of poly ICLC in rabbits yields very high plasma interferon (IFN) levels; dosages from 250 to 1000 micrograms/kg body weight are very toxic. Subcutaneous administration of poly ICLC together with a high concentration of human serum albumin potentiates the inducer activity in comparison to poly ICLC in saline. Finally, a dosage of 50 micrograms of poly ICLC in 12% serum albumin is more effective as an IFN inducer than other dosages.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Albumins
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Animals
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Carboxymethylcellulose Sodium / administration & dosage
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Carboxymethylcellulose Sodium / pharmacology*
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Injections, Intravenous
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Injections, Subcutaneous
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Interferon Inducers / administration & dosage
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Interferon Inducers / pharmacology*
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Interferons / biosynthesis
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Interferons / blood*
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Male
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Methylcellulose / analogs & derivatives*
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Poly I-C / administration & dosage
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Poly I-C / pharmacology*
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Polylysine / administration & dosage
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Polylysine / pharmacology*
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Rabbits
Substances
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Albumins
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Interferon Inducers
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Polylysine
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poly ICLC
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Methylcellulose
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Interferons
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Carboxymethylcellulose Sodium
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Poly I-C