Novel inhibitor of DNA ligase IV with a promising cancer therapeutic potential

J Biosci. 2014 Jun;39(3):339-40. doi: 10.1007/s12038-014-9433-0.
No abstract available

MeSH terms

  • Animals
  • Cell Line, Tumor
  • DNA End-Joining Repair / drug effects
  • DNA Ligase ATP
  • DNA Ligases / antagonists & inhibitors*
  • DNA Repair
  • Drug Evaluation, Preclinical
  • Humans
  • Mice
  • Neoplasms / drug therapy*
  • Pyrimidines / adverse effects
  • Pyrimidines / therapeutic use*
  • Schiff Bases / adverse effects
  • Schiff Bases / therapeutic use*

Substances

  • 5,6-bis(benzylideneamino)-2-mercaptopyrimidin-4-ol
  • LIG4 protein, human
  • Pyrimidines
  • Schiff Bases
  • DNA Ligases
  • DNA Ligase ATP