Intestinal decontamination of multidrug-resistant Klebsiella pneumoniae after recurrent infections in an immunocompromised host

Matthew P Kronman; Danielle M Zerr; Xuan Qin; Janet Englund; Cathy Cornell; Jean E Sanders; Jeffrey Myers; Jaipreet Rayar; Jessica E Berry; Amanda L Adler; Scott J Weissman

doi:10.1016/j.diagmicrobio.2014.06.006

Intestinal decontamination of multidrug-resistant Klebsiella pneumoniae after recurrent infections in an immunocompromised host

Diagn Microbiol Infect Dis. 2014 Sep;80(1):87-9. doi: 10.1016/j.diagmicrobio.2014.06.006. Epub 2014 Jun 21.

Authors

Affiliations

¹ Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA; Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA. Electronic address: [email protected].
² Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA; Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
³ Microbiology laboratory, Seattle Children's Hospital, Seattle, WA, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
⁴ Division of Infectious Diseases, University of Washington, Seattle, WA, USA.
⁵ Division of Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁶ Center for Childhood Infections and Prematurity Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
⁷ Center for Clinical and Translational Research, Seattle Children's Hospital Research Institute, Seattle, WA, USA.
⁸ Department of Pediatrics, University of Washington, Seattle, WA, USA; Division of Infectious Diseases, University of Washington, Seattle, WA, USA.

Abstract

Multidrug-resistant (MDR) Enterobacteriaceae infections are associated with increased morbidity. We describe a 20-year-old hematopoietic cell transplantation recipient with recurrent MDR Klebsiella pneumoniae infection, prolonged intestinal colonization, and subsequent intestinal decontamination. Further study should evaluate stool surveillance, molecular typing, and fecal microbiota transplantation for patients with intestinal MDR Enterobacteriaceae carriage.

Keywords: Hematopoietic cell transplantation; Intestinal decontamination; Klebsiella pneumoniae; Pediatrics; Resistance.

Publication types

Case Reports
Research Support, N.I.H., Extramural

MeSH terms

Adult
Anti-Bacterial Agents / administration & dosage*
Bacteremia / drug therapy
Bacteremia / microbiology
Drug Resistance, Multiple, Bacterial
Feces / microbiology
Hematopoietic Stem Cell Transplantation
Humans
Immunocompromised Host
Klebsiella Infections / drug therapy
Klebsiella Infections / microbiology*
Klebsiella pneumoniae / classification
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / genetics
Male
Recurrence
Skin Diseases, Bacterial / drug therapy
Skin Diseases, Bacterial / microbiology
Transplant Recipients
Young Adult

Substances

Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding