Macromolecule loading into spherical, elliptical, star-like and cubic calcium carbonate carriers

Chemphyschem. 2014 Sep 15;15(13):2817-22. doi: 10.1002/cphc.201402136. Epub 2014 Jul 10.

Abstract

We fabricated calcium carbonate particles with spherical, elliptical, star-like and cubical morphologies by varying relative salt concentrations and adding ethylene glycol as a solvent to slow down the rate of particle formation. The loading capacity of particles of different isotropic (spherical and cubical) and anisotropic (elliptical and star-like) geometries is investigated, and the surface area of such carriers is analysed. Potential applications of such drug delivery carriers are highlighted.

Keywords: adsorption; calcium; drug delivery; nanoparticles; solid-state structures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium Carbonate / chemical synthesis
  • Calcium Carbonate / chemistry*
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Drug Delivery Systems
  • Ethylene Glycol / chemistry
  • Macromolecular Substances / chemical synthesis
  • Macromolecular Substances / chemistry
  • Particle Size
  • Surface Properties

Substances

  • Drug Carriers
  • Macromolecular Substances
  • Ethylene Glycol
  • Calcium Carbonate