Abstract
A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Cohort Studies
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Drug Resistance, Viral*
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Female
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Genotype
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HIV Infections / drug therapy*
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HIV Infections / virology*
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HIV Protease Inhibitors / therapeutic use*
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HIV-1 / classification
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HIV-1 / genetics*
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HIV-1 / isolation & purification
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Humans
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Indien
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Male
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Middle Aged
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Mutagenesis, Insertional*
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Treatment Failure
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gag Gene Products, Human Immunodeficiency Virus / genetics*
Substances
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HIV Protease Inhibitors
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gag Gene Products, Human Immunodeficiency Virus
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p6 gag protein, Human immunodeficiency virus 1