Enantioselective carbocycle formation through intramolecular Pd-catalyzed allyl-aryl cross-coupling

Org Lett. 2014 Sep 5;16(17):4420-3. doi: 10.1021/ol5019163. Epub 2014 Aug 8.

Abstract

Aryl electrophiles containing tethered allylboronate units undergo efficient intramolecular coupling in the presence of a chiral palladium catalyst to give enantioenriched carbocyclic products. The reaction is found to be quite general, affording 5, 6, and 7-membered carbocyclic products as single regioisomers and with moderate enantioselectivities. Examination of differential coupling partners points to rapid allyl-equilibration as a key stereodefining feature.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemistry*
  • Catalysis
  • Cyclization
  • Molecular Structure
  • Palladium / chemistry*
  • Polycyclic Compounds / chemical synthesis*
  • Polycyclic Compounds / chemistry
  • Stereoisomerism

Substances

  • Boronic Acids
  • Polycyclic Compounds
  • Palladium