Vascular challenges in renal transplantation

Ann Transplant. 2014 Sep 19:19:464-71. doi: 10.12659/AOT.890893.

Abstract

Background: The increasing demand for transplantable organs, especially kidneys, has led to expanded criteria for renal transplant donors. As a result of the expanded criteria, more organs with vascular anomalies and/or pathologies are available for transplant. This retrospective study evaluated the impact of vascular repair on the outcome in kidney transplantation in a single center over a 15-year period.

Material and methods: Between January 1997 and May 2012, 1134 deceased donor renal transplantations were performed in the Department for Vascular and Endovascular Surgery of the University of Düsseldorf, Germany.

Results: A vascular reconstruction of some type was necessary to repair renal vessels or to prepare the recipient site for transplantation in 374 of 1134 (33.0%) renal transplantations. The iliac artery in 12.3% (139/1134) of cases and the renal artery in 10.1% (115/1134) of cases showed severe atherosclerosis and a thrombo-endarterectomy was required. Organ loss occurred in 13 cases (1.1%) due to vascular failure. The 5-year graft survival for kidneys with reconstructed renal arteries was 84.3% in deceased donor renal transplantations (86.1% without arterial reconstruction).

Conclusions: The demand for renal transplants has led to more marginal-quality organs and older donors and/or recipients waiting for a second or third transplantation. Thus, the expertise of a vascular surgeon is extremely helpful in a transplantation center because it allows for marginal organ transplantation with acceptable 5-year graft survival rates.

MeSH terms

  • Adult
  • Aged
  • Atherosclerosis / pathology
  • Atherosclerosis / surgery
  • Donor Selection
  • Endarterectomy
  • Female
  • Graft Survival
  • Humans
  • Iliac Artery / pathology
  • Iliac Artery / surgery
  • Kidney / blood supply*
  • Kidney / pathology
  • Kidney / surgery
  • Kidney Transplantation / adverse effects
  • Kidney Transplantation / methods*
  • Male
  • Middle Aged
  • Postoperative Complications / etiology
  • Renal Artery / pathology
  • Renal Artery / surgery
  • Renal Veins / pathology
  • Renal Veins / surgery
  • Retrospective Studies
  • Tissue Donors
  • Tissue and Organ Harvesting