Abstract
The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bone Morphogenetic Proteins / metabolism
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Fracture Healing
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Fractures, Bone / metabolism
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Fractures, Bone / pathology
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Glycogen Synthase Kinase 3 / metabolism
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Humans
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LDL-Receptor Related Proteins / metabolism
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Wnt Proteins / metabolism*
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Wnt Signaling Pathway
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beta Catenin / metabolism
Substances
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Bone Morphogenetic Proteins
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LDL-Receptor Related Proteins
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Wnt Proteins
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beta Catenin
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Glycogen Synthase Kinase 3