Abstract
The histone-modifying PRC2 complex has an ambiguous role in cancer, bearing both oncogenic and tumor-suppressive features depending on cell type. Studies of malignant peripheral nerve sheath tumors (MPNSTs) have now identified loss-of-function mutations altering PRC2 subunits, leading to the amplification of Ras-driven transcription and conferring vulnerability to BRD4 inhibitors.
MeSH terms
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Cell Cycle Proteins
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Genes, Neurofibromatosis 1 / physiology
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Humans
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Models, Biological*
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Neoplasm Proteins
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Neurilemmoma / genetics*
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Nuclear Proteins / antagonists & inhibitors
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Polycomb Repressive Complex 2 / deficiency*
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Polycomb Repressive Complex 2 / genetics
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Signal Transduction / genetics
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Signal Transduction / physiology*
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Transcription Factors / antagonists & inhibitors
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Transcription, Genetic / physiology
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ras Proteins / metabolism*
Substances
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BRD4 protein, human
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Cell Cycle Proteins
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EED protein, human
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Neoplasm Proteins
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Nuclear Proteins
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SUZ12 protein, human
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Transcription Factors
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Polycomb Repressive Complex 2
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ras Proteins