Particle therapy for non-small cell lung tumors: where do we stand? A systematic review of the literature

Krista C J Wink; Erik Roelofs; Timothy Solberg; Liyong Lin; Charles B Simone 2nd; Annika Jakobi; Christian Richter; Philippe Lambin; Esther G C Troost

doi:10.3389/fonc.2014.00292

Particle therapy for non-small cell lung tumors: where do we stand? A systematic review of the literature

Front Oncol. 2014 Oct 29:4:292. doi: 10.3389/fonc.2014.00292. eCollection 2014.

Authors

Krista C J Wink¹, Erik Roelofs¹, Timothy Solberg², Liyong Lin², Charles B Simone 2nd², Annika Jakobi³, Christian Richter⁴, Philippe Lambin¹, Esther G C Troost¹

Affiliations

¹ Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre , Maastricht , Netherlands.
² Department of Radiation Oncology, Hospital of the University of Pennsylvania , Philadelphia, PA , USA.
³ OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf , Dresden , Germany.
⁴ OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf , Dresden , Germany ; German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ) , Heidelberg , Germany.

Abstract

This review article provides a systematic overview of the currently available evidence on the clinical effectiveness of particle therapy for the treatment of non-small cell lung cancer and summarizes findings of in silico comparative planning studies. Furthermore, technical issues and dosimetric uncertainties with respect to thoracic particle therapy are discussed.

Keywords: C-ion; IMPT; NSCLC; PBS; PSPT; photon; proton; radiotherapy.

Publication types

Review