Pharmacological aspects of release from microcapsules - from polymeric multilayers to lipid membranes

Pieter Wuytens; Bogdan Parakhonskiy; Alexey Yashchenok; Mathias Winterhalter; Andre Skirtach

doi:10.1016/j.coph.2014.09.016

Pharmacological aspects of release from microcapsules - from polymeric multilayers to lipid membranes

Curr Opin Pharmacol. 2014 Oct:18:129-40. doi: 10.1016/j.coph.2014.09.016. Epub 2014 Oct 14.

Authors

Pieter Wuytens¹, Bogdan Parakhonskiy², Alexey Yashchenok³, Mathias Winterhalter⁴, Andre Skirtach⁵

Affiliations

¹ Photonics Research Group, Department of Information Technology, Ghent University - imec, B-9000 Ghent, Belgium; Department of Molecular Biotechnology, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium.
² A.V. Shubnikov Institute of Crystallography RAS, 119333 Moscow, Russia; Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia.
³ Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia; Max-Planck-Institute of Colloids and Interfaces, 14476 Potsdam, Germany.
⁴ Biophysics, School of Engineering and Sciences, Jacobs University of Bremen, 28759 Bremen, Germany.
⁵ Department of Molecular Biotechnology, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium; Center for Nano- and Biophotonics (NB-Photonics), Ghent University, Belgium; Max-Planck-Institute of Colloids and Interfaces, 14476 Potsdam, Germany. Electronic address: [email protected].

PMID: 25450067
DOI: 10.1016/j.coph.2014.09.016

Abstract

This review is devoted to pharmacological applications of principles of release from capsules to overcome the membrane barrier. Many of these principles were developed in the context of polymeric multilayer capsule membrane modulation, but they are also pertinent to liposomes, polymersomes, capsosomes, particles, emulsion-based carriers and other carriers. We look at these methods from the physical, chemical or biological driving mechanisms point of view. In addition to applicability for carriers in drug delivery, these release methods are significant for another area directly related to pharmacology - modulation of the permeability of the membranes and thus promoting the action of drugs. Emerging technologies, including ionic current monitoring through a lipid membrane on a nanopore, are also highlighted.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Capsules* / administration & dosage
Capsules* / chemistry
Cell Membrane / metabolism
Drug Carriers* / administration & dosage
Drug Carriers* / chemistry
Humans
Membrane Lipids / metabolism
Polymers* / administration & dosage
Polymers* / chemistry

Substances

Capsules
Drug Carriers
Membrane Lipids
Polymers