Predictive and prognostic value of circulating tumor cell detection in lung cancer: a clinician's perspective

Annette Tognela; Kevin J Spring; Therese Becker; Nicole J Caixeiro; Victoria J Bray; Po Yee Yip; Wei Chua; Stephanie H Lim; Paul de Souza

doi:10.1016/j.critrevonc.2014.10.001

Predictive and prognostic value of circulating tumor cell detection in lung cancer: a clinician's perspective

Crit Rev Oncol Hematol. 2015 Feb;93(2):90-102. doi: 10.1016/j.critrevonc.2014.10.001. Epub 2014 Oct 12.

Authors

Annette Tognela¹, Kevin J Spring², Therese Becker², Nicole J Caixeiro³, Victoria J Bray⁴, Po Yee Yip⁵, Wei Chua⁶, Stephanie H Lim⁷, Paul de Souza⁸

Affiliations

¹ Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; Macarthur Clinical School, University of Western Sydney, Campbelltown 2560, Australia; Department of Medical Oncology, Campbelltown Hospital, Campbelltown 2560, Australia. Electronic address: [email protected].
² Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; School of Medicine, University of New South Wales, Kensington 2052, Australia.
³ Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia.
⁴ Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia.
⁵ Department of Medical Oncology, Campbelltown Hospital, Campbelltown 2560, Australia; Sydney Medical School, University of Sydney, Camperdown 2006, Australia.
⁶ Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia.
⁷ Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; School of Medicine, University of New South Wales, Kensington 2052, Australia.
⁸ Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool 2170, Australia; Department of Medical Oncology, Liverpool Hospital, Liverpool 2170, Australia; South West Sydney Translational Cancer Research Unit, Liverpool 2170, Australia; School of Medicine, University of New South Wales, Kensington 2052, Australia; Macarthur Clinical School, University of Western Sydney, Campbelltown 2560, Australia.

PMID: 25459665
DOI: 10.1016/j.critrevonc.2014.10.001

Abstract

There is increasing evidence for the use of circulating tumor cells (CTCs) as a "liquid biopsy" for early detection of lung cancer recurrence, prognosticating disease and monitoring treatment response. Further, CTC molecular analysis and interrogation of single cells hold significant potential in providing insights into tumor biology and the metastatic process. Ongoing research will likely see the translation of CTCs as a prognostic and predictive biomarker in both small cell, and non-small cell, lung cancer to routine clinical practice.

Keywords: Biomarkers; Circulating tumor cells; Lung cancer; Non-small cell; Small cell.

Publication types

Review

MeSH terms

Antineoplastic Agents / therapeutic use
Biological Assay
Biomarkers, Tumor / analysis*
Biopsy
Carcinoma, Non-Small-Cell Lung / diagnosis*
Carcinoma, Non-Small-Cell Lung / pathology
Carcinoma, Non-Small-Cell Lung / therapy
Cell Count
Cell Separation / methods
Early Diagnosis
Gamma Rays / therapeutic use
Humans
Lung Neoplasms / diagnosis*
Lung Neoplasms / pathology
Lung Neoplasms / therapy
Neoplasm Staging
Neoplastic Cells, Circulating / pathology*
Prognosis
Prospective Studies
Single-Cell Analysis / instrumentation
Single-Cell Analysis / methods

Substances

Antineoplastic Agents
Biomarkers, Tumor