Abstract
Simian immunodeficiency virus (SIV)/Mne has been inoculated into three species of macaques and into baboons. Virus was isolated from all the macaques who subsequently died at 15 to 120 weeks (mean 80 weeks) with various manifestations of immune deficiency. Individual animals varied in their viral antibody profile as a function of time after infection. Independent SIV isolates obtained from African green monkeys and magabeys were compared to SIV/Mne for their ability to replicate in lymphocytes and macrophages and with respect to the immunological relatedness of their viral proteins. Antibodies present in human immunodeficiency virus-2 (HIV-2)-infected individuals were readily detected by the virus produced by a single-cell clone of SIV/Mne.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antibodies, Viral / biosynthesis*
-
Cell Line
-
Cercopithecidae / microbiology*
-
Chlorocebus aethiops / microbiology
-
Cross Reactions
-
Female
-
HIV Antibodies / analysis
-
HIV-1 / immunology
-
HIV-2 / immunology
-
Humans
-
Immunoblotting
-
Lymphocytes / microbiology
-
Macaca / microbiology
-
Monkey Diseases / immunology*
-
Papio / microbiology
-
Retroviridae Infections / immunology
-
Retroviridae Infections / veterinary*
-
Retroviridae Proteins / analysis
-
Retroviridae Proteins / isolation & purification
-
Simian Immunodeficiency Virus / genetics
-
Simian Immunodeficiency Virus / immunology*
-
Simian Immunodeficiency Virus / isolation & purification
Substances
-
Antibodies, Viral
-
HIV Antibodies
-
Retroviridae Proteins