Advancements in the development of subunit influenza vaccines

Naru Zhang; Bo-Jian Zheng; Lu Lu; Yusen Zhou; Shibo Jiang; Lanying Du

doi:10.1016/j.micinf.2014.12.006

Advancements in the development of subunit influenza vaccines

Microbes Infect. 2015 Feb;17(2):123-34. doi: 10.1016/j.micinf.2014.12.006. Epub 2014 Dec 18.

Authors

Naru Zhang¹, Bo-Jian Zheng², Lu Lu³, Yusen Zhou⁴, Shibo Jiang⁵, Lanying Du⁶

Affiliations

¹ Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA.
² Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong.
³ Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China.
⁴ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
⁵ Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China. Electronic address: [email protected].
⁶ Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA. Electronic address: [email protected].

Abstract

The ongoing threat of influenza epidemics and pandemics has emphasized the importance of developing safe and effective vaccines against infections from divergent influenza viruses. In this review, we first introduce the structure and life cycle of influenza A viruses, describing major influenza A virus-caused pandemics. We then compare different types of influenza vaccines and discuss current advancements in the development of subunit influenza vaccines, particularly those based on nucleoprotein (NP), extracellular domain of matrix protein 2 (M2e) and hemagglutinin (HA) proteins. We also illustrate potential strategies for improving the efficacy of subunit influenza vaccines.

Keywords: Hemagglutinin; Influenza A virus; Matrix protein; Nucleoprotein; Subunit vaccines.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Influenza A virus / immunology
Influenza A virus / pathogenicity
Influenza A virus / physiology
Influenza Vaccines / genetics*
Influenza Vaccines / immunology
Influenza Vaccines / therapeutic use
Vaccines, Subunit / genetics
Vaccines, Subunit / immunology

Substances

Influenza Vaccines
Vaccines, Subunit

Abstract

Publication types

MeSH terms

Substances

Grants and funding