A novel poly(γ-glutamic acid)/silk-sericin hydrogel for wound dressing: Synthesis, characterization and biological evaluation

Mater Sci Eng C Mater Biol Appl. 2015 Mar:48:533-40. doi: 10.1016/j.msec.2014.12.047. Epub 2014 Dec 11.

Abstract

A novel multifunctional poly(γ-glutamic acid)/silk sericin (γ-PGA/SS) hydrogel has been developed and used as wound dressing. The physical and chemical properties of the γ-PGA/SS gels were systemically investigated. Furthermore, these γ-PGA/SS gels have been found to promote the L929 fibroblast cells proliferate, and in the in vivo study, significant stimulatory effects were also observed on granulation and capillary formation on day 9 in H-2-treated wounds, indicating that this new complex hydrogel could maintain a moist healing environment, protect the wound from bacterial infection, absorb excess exudates, and promote cell proliferation to reconstruct damaged tissue. Considering the simple preparation process and excellent biological property, this γ-PGA/SS hydrogel might have a wide range of applications in biomedical and clinical areas.

Keywords: Hydrogel; Poly(γ-glutamic acid); Silk sericin; Wound dressing.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biological Dressings*
  • Cell Line
  • Drug Evaluation, Preclinical
  • Fibroblasts / metabolism*
  • Fibroblasts / pathology
  • Hydrogel, Polyethylene Glycol Dimethacrylate* / chemistry
  • Hydrogel, Polyethylene Glycol Dimethacrylate* / pharmacology
  • Mice
  • Polyglutamic Acid* / chemistry
  • Polyglutamic Acid* / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Sericins* / chemistry
  • Sericins* / pharmacology
  • Wound Healing / drug effects*
  • Wound Infection / prevention & control*

Substances

  • Sericins
  • Polyglutamic Acid
  • Hydrogel, Polyethylene Glycol Dimethacrylate