Factors affecting ¹⁸F FDOPA standardized uptake value in patients with primary brain tumors after treatment

Nucl Med Biol. 2015 Apr;42(4):355-9. doi: 10.1016/j.nucmedbio.2015.01.002. Epub 2015 Jan 9.

Abstract

Aim: To investigate the factors affecting (18)F FDOPA uptake in patients with primary brain tumors (PBT) after treatment.

Materials and methods: 97 patients with PBT (6 were grade I, 40 were grade II, 29 were grade III and 22 were grade IV) underwent (18)F FDOPA positron emission tomography/computed tomography (PET/CT) after treatment. Intervals from surgery, chemotherapy (CHT) and radiotherapy (RT) were 41.48 (±42.27), 16.04 (±29.08) and 28.62 (±34.49) months respectively.

Results: (18)F FDOPA uptake in the site of recurrence was not related to the interval from surgery and CHT while a significant relationship has been found with the interval from RT and tumor grade.

Conclusions: The results of our study show that the interval from RT and the grade of PBT should be considered carefully when evaluating brain PET/CT scans since these factors could directly affect (18)F FDOPA uptake.

Keywords: (18)F FDOPA; Chemotherapy; Primary brain tumors; Radiotherapy; SUV; Surgery.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biological Transport / drug effects
  • Biological Transport / radiation effects
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / therapy*
  • Dihydroxyphenylalanine / analogs & derivatives*
  • Dihydroxyphenylalanine / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Positron-Emission Tomography
  • Tomography, X-Ray Computed
  • Young Adult

Substances

  • fluorodopa F 18
  • Dihydroxyphenylalanine