Reactivation of hepatitis B virus without core antibody

André Silva-Pinto; Joaquim Andrade; Fernando Araújo; Lurdes Santos; António Sarmento

doi:10.1128/JCM.03546-14

Reactivation of hepatitis B virus without core antibody

J Clin Microbiol. 2015 Apr;53(4):1434-5. doi: 10.1128/JCM.03546-14. Epub 2015 Jan 28.

Authors

André Silva-Pinto¹, Joaquim Andrade², Fernando Araújo³, Lurdes Santos⁴, António Sarmento⁴

Affiliations

¹ Infectious Diseases Department, Hospital São João, Porto, Portugal Faculty of Medicine of University of Porto, Porto, Portugal [email protected].
² Haematology Department, Hospital São João, Porto, Portugal.
³ Faculty of Medicine of University of Porto, Porto, Portugal Blood Bank and Transfusion Medicine Department, Hospital São João, Porto, Portugal.
⁴ Infectious Diseases Department, Hospital São João, Porto, Portugal Faculty of Medicine of University of Porto, Porto, Portugal.

Abstract

We present the case of a male patient not vaccinated against hepatitis B virus (HBV) and with reactivity to a surface antibody who, after immunosuppression for a multiple myeloma, had HBV reactivation. Pharmacological HBV suppression was tried, but viremia could not be suppressed. Production-detection core mutations or immunity issues can explain this clinical phenomenon.

Publication types

Case Reports

MeSH terms

Antiviral Agents / therapeutic use
Guanine / analogs & derivatives
Guanine / therapeutic use
Hematopoietic Stem Cell Transplantation
Hepatitis B / diagnosis*
Hepatitis B / drug therapy
Hepatitis B / immunology
Hepatitis B Antibodies / blood*
Hepatitis B Antibodies / immunology
Hepatitis B Core Antigens / immunology*
Hepatitis B virus / immunology*
Humans
Male
Middle Aged
Multiple Myeloma / therapy

Substances

Antiviral Agents
Hepatitis B Antibodies
Hepatitis B Core Antigens
entecavir
Guanine