Temporal changes in neurotrophic factors and neurite outgrowth in the major pelvic ganglion following cavernous nerve injury

J Neurosci Res. 2015 Jun;93(6):954-63. doi: 10.1002/jnr.23553. Epub 2015 Jan 19.

Abstract

Despite nerve-sparing radical prostatectomy, nerve damage and erectile dysfunction (ED) prevail, and preventing neurodegeneration is of great importance. Neurotrophic factors and neurite outgrowth were characterized in major pelvic ganglia (MPG) following bilateral cavernous nerve injury (BCNI). Young male Sprague-Dawley rats underwent sham or BCNI surgery, and the intracavernosal pressure to mean arterial pressure ratio was measured 2, 7, 14, 21, 30, and 60 days following injury (n = 8/group). MPG gene expression (qPCR) and Western blot were performed for glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurturin, neurotrophin (NT)-3, NT4, brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor, and activating transcription factor 3 (ATF3). Additional rats were injured, and MPGs were removed 24 hr, 48 hr, 3 days, and 7 days following BCNI (n = 3/group). MPGs were cultured in Matrigel, and neurite outgrowth was measured. Erections were impaired early and improved by 60 days in BCNI rats. GDNF, NGF, BDNF, and ATF3 gene expression was significantly increased and NT3 was decreased in MPGs following BCNI (48 hr to 21 days, P < 0.05). GDNF and NGF protein levels were elevated in 48-hr BCNI rats. MPG neurite outgrowth from 24-hr and 48-hr BCNI was higher than sham (658 ± 19 μm, 607 ± 24 μm, 393 ± 23 μm, respectively, P < 0.05). Further studies examining the roles of neurotrophic factors in modulating signaling pathways may provide therapeutic avenues for neurogenically mediated ED.

Keywords: activating transcription factor 3; erectile dysfunction; neurite outgrowth; peripheral nerve injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Blood Pressure / physiology
  • Cell Culture Techniques
  • Disease Models, Animal
  • Erectile Dysfunction / etiology
  • Ganglia, Sympathetic / metabolism*
  • Ganglia, Sympathetic / pathology*
  • Gene Expression Regulation / physiology
  • Hypoxanthine Phosphoribosyltransferase / metabolism
  • Male
  • Nerve Growth Factors / genetics
  • Nerve Growth Factors / metabolism*
  • Neurites / physiology*
  • Peripheral Nerve Injuries / complications
  • Peripheral Nerve Injuries / pathology*
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Statistics as Topic

Substances

  • Nerve Growth Factors
  • RNA, Messenger
  • Hypoxanthine Phosphoribosyltransferase