Survey on etiological diagnosis of diabetes in 1244 Italian diabetic children and adolescents: impact of access to genetic testing

Enza Mozzillo; Giuseppina Salzano; Fabrizio Barbetti; Claudio Maffeis; Fortunato Lombardo; Adriana Franzese; Maurizio Delvecchio; Marco Marigliano

doi:10.1016/j.diabres.2015.01.003

Survey on etiological diagnosis of diabetes in 1244 Italian diabetic children and adolescents: impact of access to genetic testing

Diabetes Res Clin Pract. 2015 Mar;107(3):e15-8. doi: 10.1016/j.diabres.2015.01.003. Epub 2015 Jan 20.

Authors

Enza Mozzillo¹, Giuseppina Salzano², Fabrizio Barbetti³, Claudio Maffeis⁴, Fortunato Lombardo², Adriana Franzese¹, Maurizio Delvecchio⁵, Marco Marigliano⁴

Affiliations

¹ Department of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
² Department of Pediatric Sciences, University of Messina, Messina, Italy.
³ Department of Experimental Medicine and Surgery, University of Tor Vergata and Bambino Gesù Children's Hospital, IRCCS, Rome, 00134 Italy. Electronic address: [email protected].
⁴ Regional Center for Pediatric Diabetes, Clinical Nutrition and Obesity, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
⁵ "B Trambusti" Paediatrics Unit, Department of Biomedical Sciences and Human Oncology, AOU Policlinico Consorziale of Bari, Bari, 70100, Italy. Electronic address: [email protected].

PMID: 25649912
DOI: 10.1016/j.diabres.2015.01.003

Abstract

Type 2 and monogenic diabetes are emerging causes of diabetes in youths. Among 1244 Italian patients <18 years of age, 91.9% had type 1, 0.2% type 2, and 4.9% monogenic diabetes. Monogenic diabetes ranks second as a cause of diabetes in Italian youth, while type 2 diabetes appears to be rare.

Keywords: Diabetes mellitus; Monogenic diabetes; Type 2 diabetes.

MeSH terms

Adolescent
Age of Onset
Child
Data Collection
Diabetes Mellitus / classification
Diabetes Mellitus / diagnosis*
Diabetes Mellitus / epidemiology
Diabetes Mellitus / genetics*
Diabetes Mellitus, Type 1 / diagnosis
Diabetes Mellitus, Type 1 / epidemiology
Diabetes Mellitus, Type 1 / genetics
Diabetes Mellitus, Type 2 / diagnosis
Diabetes Mellitus, Type 2 / epidemiology
Diabetes Mellitus, Type 2 / genetics
Diagnosis, Differential
Genetic Testing*
Humans
Italy / epidemiology
White People / genetics