Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration

Renan O Silva; Samara R B Damasceno; Irismara S Silva; Valdelânia G Silva; Camila F C Brito; Antônio Éder A Teixeira; Geandra B L Nunes; Celso A Camara; José Maria B Filho; Stanley J C Gutierrez; Ronaldo A Ribeiro; Marcellus H L P Souza; André L R Barbosa; Rivelilson M Freitas; Jand Venes R Medeiros

doi:10.1016/j.cbi.2015.01.029

Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration

Chem Biol Interact. 2015 Mar 5:229:55-63. doi: 10.1016/j.cbi.2015.01.029. Epub 2015 Feb 3.

Authors

Renan O Silva¹, Samara R B Damasceno¹, Irismara S Silva², Valdelânia G Silva², Camila F C Brito², Antônio Éder A Teixeira¹, Geandra B L Nunes³, Celso A Camara⁴, José Maria B Filho⁵, Stanley J C Gutierrez⁶, Ronaldo A Ribeiro¹, Marcellus H L P Souza¹, André L R Barbosa², Rivelilson M Freitas³, Jand Venes R Medeiros⁷

Affiliations

¹ Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
² Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil.
³ Laboratory for Research in Experimental Neurochemistry, Federal University of Piauí, Teresina, PI, Brazil.
⁴ Molecular Sciences Department, Federal Rural University of Pernambuco, Recife, PE, Brazil.
⁵ Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB, Brazil.
⁶ Laboratory Chemistry of Bioactive Natural and Synthetic Products, Federal University of Piauí, Teresina, PI, Brazil.
⁷ Post-Graduation Program in Biotechnology, Federal University of Piauí, Parnaíba, PI, Brazil. Electronic address: [email protected].

PMID: 25656915
DOI: 10.1016/j.cbi.2015.01.029

Abstract

Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.

Keywords: Inflammation; Neutrophil; Oxidative stress; Riparin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / therapeutic use*
Antioxidants / isolation & purification
Antioxidants / therapeutic use
Benzamides / isolation & purification
Benzamides / therapeutic use*
Carrageenan / adverse effects*
Carrageenan / immunology
Cell Adhesion / drug effects
Cytokines / immunology
Edema / chemically induced
Edema / drug therapy*
Edema / immunology
Edema / pathology
Extremities / pathology
Immune System Diseases / chemically induced
Immune System Diseases / drug therapy*
Immune System Diseases / immunology
Immune System Diseases / pathology
Inflammation / chemically induced
Inflammation / drug therapy
Inflammation / immunology
Inflammation / pathology
Lauraceae / chemistry
Leukocyte Disorders / chemically induced
Leukocyte Disorders / drug therapy*
Leukocyte Disorders / immunology
Leukocyte Disorders / pathology
Leukocyte Rolling / drug effects
Male
Mice
Neutrophils / drug effects*
Neutrophils / immunology
Neutrophils / pathology
Oxidative Stress / drug effects
Peritonitis / chemically induced
Peritonitis / drug therapy*
Peritonitis / immunology
Peritonitis / pathology
Peroxidase / immunology
Phenethylamines / isolation & purification
Phenethylamines / therapeutic use*

Substances

Anti-Inflammatory Agents
Antioxidants
Benzamides
Cytokines
N-phenethylbenzamide
Phenethylamines
Carrageenan
Peroxidase

Supplementary concepts

Neutrophil Chemotactic Response, Abnormal