A facile strategy to generate polymeric nanoparticles for synergistic chemo-photodynamic therapy

Chem Commun (Camb). 2015 Mar 11;51(20):4271-4. doi: 10.1039/c4cc10226f.

Abstract

Synergistic therapy is a promising strategy for cancer treatment. A nanoparticle with chemo-photodynamic properties was fabricated via π-π stacking interactions between the drug and photosensitizer. It exhibited efficient anticancer activity both in vitro and in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Doxorubicin / administration & dosage*
  • Doxorubicin / chemistry
  • Humans
  • Mammary Neoplasms, Animal / drug therapy
  • Mammary Neoplasms, Animal / pathology
  • Mice, Nude
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Photochemotherapy*
  • Photosensitizing Agents / administration & dosage*
  • Photosensitizing Agents / chemistry
  • Polyethylene Glycols / administration & dosage*
  • Polyethylene Glycols / chemistry
  • Tumor Burden / drug effects

Substances

  • Antineoplastic Agents
  • Photosensitizing Agents
  • Polyethylene Glycols
  • Doxorubicin
  • monomethoxypolyethylene glycol