Influenza virus activation of the interferon system

Marian J Killip; Ervin Fodor; Richard E Randall

doi:10.1016/j.virusres.2015.02.003

Influenza virus activation of the interferon system

Virus Res. 2015 Nov 2:209:11-22. doi: 10.1016/j.virusres.2015.02.003. Epub 2015 Feb 9.

Authors

Marian J Killip¹, Ervin Fodor², Richard E Randall³

Affiliations

¹ Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Electronic address: [email protected].
² Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
³ Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK.

Abstract

The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.

Keywords: Influenza viruses; Innate immunity; Interferon; RIG-I.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Defective Viruses / immunology
Host-Pathogen Interactions*
Humans
Immunity, Innate*
Interferon Type I / metabolism*
Orthomyxoviridae / immunology*
Orthomyxoviridae / physiology*

Substances

Interferon Type I

Abstract

Publication types

MeSH terms

Substances

Grants and funding