Abstract
We have isolated from a human genomic library a pseudogene of the proliferating cell nuclear antigen (PCNA) gene. Its sequence shows a 78% similarity with the human PCNA/cDNA. The PCNA gene is located on human chromosome 20, while the pseudogene maps to chromosome region Xpter in equilibrium Xq13. An additional locus detected by the full-length PCNA cDNA, but not by intron probes, segregates concordantly with chromosome region 6p12 in equilibrium 6pter and probably represents a second pseudogene.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Southern
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Chromosome Mapping
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Chromosomes, Human, Pair 20*
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Chromosomes, Human, Pair 6
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Cloning, Molecular
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DNA / genetics
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DNA Probes
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Humans
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Hybrid Cells
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Introns
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Molecular Sequence Data
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Multigene Family
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Nuclear Proteins / genetics*
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Proliferating Cell Nuclear Antigen
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Pseudogenes*
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X Chromosome
Substances
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DNA Probes
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Nuclear Proteins
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Proliferating Cell Nuclear Antigen
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DNA