DNA-ligand interactions gained and lost: light-induced ligand redistribution in a supramolecular cascade

Daria V Berdnikova; Tseimur M Aliyeu; Thomas Paululat; Yuri V Fedorov; Olga A Fedorova; Heiko Ihmels

doi:10.1039/c5cc01025j

DNA-ligand interactions gained and lost: light-induced ligand redistribution in a supramolecular cascade

Chem Commun (Camb). 2015 Mar 21;51(23):4906-9. doi: 10.1039/c5cc01025j.

Authors

Daria V Berdnikova¹, Tseimur M Aliyeu, Thomas Paululat, Yuri V Fedorov, Olga A Fedorova, Heiko Ihmels

Affiliation

¹ Department Chemie-Biologie, Organische Chemie II, Universität Siegen, Adolf-Reichwein-Str. 2, 57068 Siegen, Germany. [email protected] [email protected].

PMID: 25704787
DOI: 10.1039/c5cc01025j

Abstract

A supramolecular five-component cascade is presented that enables light-controlled transport of an in situ modified ligand between three host systems based on the different complexation preferences of cyclodextrin, cucurbituril, and double-stranded DNA. The results point out novel approaches for the control of drug-DNA interactions in DNA-targeting therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclodextrins / chemistry*
DNA / chemistry*
DNA / radiation effects*
Drug Carriers
Drug Delivery Systems
Drug Liberation
Ligands
Light*
Macrocyclic Compounds / chemistry*
Macromolecular Substances

Substances

Cyclodextrins
Drug Carriers
Ligands
Macrocyclic Compounds
Macromolecular Substances
cucurbit(n)uril
DNA