Conserved expression of truncated telethonin in a patient with limb-girdle muscular dystrophy 2G

Neuromuscul Disord. 2015 Apr;25(4):349-52. doi: 10.1016/j.nmd.2014.12.006. Epub 2014 Dec 24.

Abstract

Limb-girdle muscular dystrophy 2G is caused by mutations in the TCAP gene that encodes for telethonin. Here we describe a 49 year-old male patient of Indian descent presenting a classical LGMD phenotype. He had normal motor milestones but became noticeably slower in his early teens and was wheelchair bound by age 44. The muscle biopsy showed myopathic features and absence of labeling with an antibody to the C-terminal portion of telethonin. Sequence analysis of the TCAP gene revealed a novel homozygous mutation in exon 2, predicted to generate a truncated protein of 81 amino acids. Interestingly, an antibody for the full-length protein showed labeling on sections and a single band of ~10 kDa on Western blot. The truncated protein co-localized with filamin C at the Z-line. Our findings indicate that mutant telethonin can be incorporated into the sarcomere and that other LGMD2G patients with retention of telethonin expression may exist.

Keywords: Immunohistochemistry; Limb-girdle muscular dystrophy; Telethonin; Western blot.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Connectin / genetics*
  • Connectin / metabolism
  • Deltoid Muscle / metabolism
  • Deltoid Muscle / pathology
  • Humans
  • Male
  • Middle Aged
  • Muscular Dystrophies, Limb-Girdle / genetics*
  • Muscular Dystrophies, Limb-Girdle / pathology
  • Muscular Dystrophies, Limb-Girdle / physiopathology
  • Mutation*
  • Sarcomeres / metabolism
  • Sarcomeres / pathology

Substances

  • Connectin
  • TCAP protein, human

Supplementary concepts

  • Muscular Dystrophy, Limb-Girdle, Type 2G