Somatic mutations of cell-free circulating DNA detected by next-generation sequencing reflect the genetic changes in both germinal center B-cell-like and activated B-cell-like diffuse large B-cell lymphomas at the time of diagnosis

Haematologica. 2015 Jul;100(7):e280-4. doi: 10.3324/haematol.2015.123612. Epub 2015 Mar 6.
No abstract available

Keywords: NGS; diffuse large B-cell lymphoma; liquid biopsy; mutations.

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • B-Lymphocytes / metabolism
  • B-Lymphocytes / pathology
  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / pathology
  • DNA, Neoplasm / genetics*
  • DNA, Neoplasm / metabolism
  • Female
  • Germinal Center / metabolism
  • Germinal Center / pathology
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Lymphocyte Activation
  • Lymphoma / diagnosis
  • Lymphoma / genetics*
  • Lymphoma / pathology
  • Lymphoma, Large B-Cell, Diffuse / diagnosis
  • Lymphoma, Large B-Cell, Diffuse / genetics*
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Male
  • Middle Aged
  • Mutation*
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism

Substances

  • DNA, Neoplasm
  • Neoplasm Proteins

Supplementary concepts

  • Progressive Transformation of Germinal Centers