New paradigms for the chiral synthesis of inositol phosphates

Chembiochem. 2015 May 4;16(7):1030-2. doi: 10.1002/cbic.201500071. Epub 2015 Mar 12.

Abstract

Paradigms found: Inositol phosphates are biomolecules found ubiquitously in eukaryotes, in which they play a number of vital biological roles. Their enantioselective synthesis has recently received a boost from two complementary phosphorylation methods that could change the way they are synthesised, and hopefully provide invaluable chemical biology tools to further our understanding of this large family.

Keywords: chiral resolution; chiral synthesis; inositol phosphate; organocatalysis; phosphorylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemistry Techniques, Synthetic
  • Inositol Phosphates / chemical synthesis*
  • Inositol Phosphates / chemistry*
  • Stereoisomerism

Substances

  • Inositol Phosphates