Enhanced dendritic integration by ih reduction in the anterior cingulate cortex increases nociception

Jasmine R Dickinson; Grégory Scherrer

doi:10.1016/j.neuron.2015.03.045

Enhanced dendritic integration by ih reduction in the anterior cingulate cortex increases nociception

Neuron. 2015 Apr 8;86(1):4-6. doi: 10.1016/j.neuron.2015.03.045.

Authors

Jasmine R Dickinson¹, Grégory Scherrer²

Affiliations

¹ Department of Anesthesiology, Perioperative and Pain Medicine, Department of Molecular and Cellular Physiology, Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA.
² Department of Anesthesiology, Perioperative and Pain Medicine, Department of Molecular and Cellular Physiology, Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA. Electronic address: [email protected].

Abstract

In this issue of Neuron, Santello and Nevian (2015) report HCN channel plasticity and increased temporal summation in layer 5 ACC neurons following nerve injury. They are able to restore HCN channel function and reduce behavioral hypersensitivity with selective serotonin receptor targeting.

Publication types

Kommentar

MeSH terms

Animals
Cerebral Cortex / pathology*
Dendrites / pathology*
Male
Neuralgia / pathology*
Neuralgia / therapy*
Neurons / pathology*
Serotonin / metabolism*

Substances

Serotonin

Grants and funding

R00 DA031777/DA/NIDA NIH HHS/United States