Polyclonal hyperviscosity syndrome in IgG4-related disease and associated conditions

Luke Yc Chen; Patrick Cw Wong; Shinji Noda; David R Collins; Gayatri M Sreenivasan; Robert C Coupland

doi:10.1002/ccr3.201

Polyclonal hyperviscosity syndrome in IgG4-related disease and associated conditions

Clin Case Rep. 2015 Apr;3(4):217-26. doi: 10.1002/ccr3.201. Epub 2015 Feb 2.

Authors

Luke Yc Chen¹, Patrick Cw Wong², Shinji Noda³, David R Collins¹, Gayatri M Sreenivasan¹, Robert C Coupland²

Affiliations

¹ Department of Medicine, University of British Columbia Vancouver, British Columbia, Canada.
² Department of Pathology and Laboratory Medicine, University of British Columbia Vancouver, British Columbia, Canada.
³ Department of Dermatology, University of Tokyo Tokyo, Japan.

Abstract

Polyclonal hyperviscosity syndrome (HVS) is rare and has been reported in various disorders of immune dysregulation and lymphoid hyperplasia. IgG4-Related Disease (IgG4-RD) is an emerging disorder often associated with exuberant hypergammaglobulinemia, and this review of seven cases establishes IgG4-RD as an important cause of polyclonal HVS.

Keywords: Hyperviscosity syndrome; IgG4 related disease; polyclonal hyperviscosity.

Publication types

Case Reports