Association of Attention Deficit Disorder With Bedside Anti-saccades in Survivors of Childhood Leukemia

J Child Neurol. 2016 Feb;31(2):131-3. doi: 10.1177/0883073815583689. Epub 2015 Apr 26.

Abstract

Impaired attention is well recognized in childhood cancer survivors. We prospectively evaluated 162 long-term survivors of childhood acute lymphoblastic leukemia to study an association between presence of neurologic soft signs as measured by Zurich Neuromotor Scale, bedside evaluation of anti-saccades, and attention deficit disorder. Attention deficit disorder was recognized in 10.5% of the study cohort. We did not find an association of attention deficit with presence of any soft sign. However, there was an association between presence of abnormal anti-saccades and attention deficit (P = .04). These results will require further validation and if confirmed may introduce a quick bedside method of assessing impaired attention in cancer survivors.

Keywords: acute lymphoblastic leukemia; anti-saccades; attention deficit disorder; childhood; soft signs.

MeSH terms

  • Adolescent
  • Adult
  • Attention Deficit Disorder with Hyperactivity / complications*
  • Child
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Point-of-Care Testing*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / physiopathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Psychiatric Status Rating Scales
  • Saccades*
  • Severity of Illness Index*
  • Survivors
  • Young Adult