Mental symptoms and quality of life in lipoprotein apheresis patients in comparison to hemodialysis patients, platelet donors and normal population

E Stasiewski; M Christoph; A Christoph; A Bittner; K Weidner; U Julius

doi:10.1016/j.atherosclerosissup.2015.02.035

Mental symptoms and quality of life in lipoprotein apheresis patients in comparison to hemodialysis patients, platelet donors and normal population

Atheroscler Suppl. 2015 May:18:233-40. doi: 10.1016/j.atherosclerosissup.2015.02.035.

Authors

E Stasiewski¹, M Christoph², A Christoph³, A Bittner⁴, K Weidner⁵, U Julius⁶

Affiliations

¹ Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Fetscherstr.74, 01307 Dresden, Germany. Electronic address: [email protected].
² Heart Center, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany. Electronic address: [email protected].
³ Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Fetscherstr.74, 01307 Dresden, Germany. Electronic address: [email protected].
⁴ Department of Psychotherapy and Psychosomatic Medicine, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany. Electronic address: [email protected].
⁵ Department of Psychotherapy and Psychosomatic Medicine, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany. Electronic address: [email protected].
⁶ Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Fetscherstr.74, 01307 Dresden, Germany. Electronic address: [email protected].

PMID: 25936331
DOI: 10.1016/j.atherosclerosissup.2015.02.035

Abstract

Background: Despite the fact that extracorporeal methods such as lipoprotein apheresis (LA) and hemodialysis (HD) are highly effective in improving the physical status of patients, these treatment options may possibly harm the psychological status and the health related quality of life (HRQL).

Methods: The occurrences of anxiety, depression and the HRQL of 111 study participants treated with LA (n = 41), HD (n = 41) or undergoing plateletpheresis (PD) (n = 29) were compared to the normal population (NP), using standardized questionnaires (anxiety and depression: Hospital Anxiety and Depression Scale (HADS), heart-focused anxiety: Cardiac Anxiety Questionnaire (CAQ) and HRQL: Short-Form Health Survey (SF-12)). Additionally, the subjective mental and physical stress of study participants was evaluated.

Results: LA females had a significantly elevated HADS-A score compared to PD and NP. Additionally, there was a trend toward higher HADS-A scores in the LA group compared to the HD group in females. In HD males HADS-A and -D scores increased compared to PD and NP. The CAQ revealed a significant increase in the CAQ-Fear scale in LA compared to HD and PD participants. The CAQ-Avoidance score showed significantly increased scores in LA and HD patients compared to PD and NP. In the CAQ-Attention scale the LA patients also showed significantly increased scores compared to PD and NP. The increased psychological symptoms were associated with significantly lower levels of objective and subjective HRQL in LA and HD patients compared to PD and NP.

Conclusions: LA and HD patients had similarly increased presence of psychological symptoms with concurrent decreased quality of life compared to PD and the normal population, which may affect the outcome of the LA patients. Therefore, early psychosomatic screening and probable psychosomatic treatment should be performed.

Keywords: Anxiety; Depression; Health-related quality of life; Hemodialysis; Lipoprotein apheresis; Mental disorders; Plateletpheresis; Psychosomatic diagnostic.

Publication types

Comparative Study

MeSH terms

Adult
Aged
Anxiety / diagnosis
Anxiety / psychology
Biomarkers / blood
Blood Component Removal / adverse effects
Blood Component Removal / psychology*
Blood Donors / psychology*
Blood Platelets*
Case-Control Studies
Cross-Sectional Studies
Depression / diagnosis
Depression / psychology
Female
Humans
Hyperlipoproteinemias / blood
Hyperlipoproteinemias / diagnosis
Hyperlipoproteinemias / psychology
Hyperlipoproteinemias / therapy*
Lipoproteins / blood*
Male
Mental Health*
Middle Aged
Quality of Life*
Registries
Renal Dialysis / adverse effects
Renal Dialysis / psychology*
Risk Factors
Sex Factors
Surveys and Questionnaires
Treatment Outcome
Young Adult

Substances

Biomarkers
Lipoproteins