Draft genome sequences of three NDM-1-producing Enterobacteriaceae species isolated from Brazil

Mem Inst Oswaldo Cruz. 2015 Jun;110(4):580-2. doi: 10.1590/0074-02760150081. Epub 2015 May 29.

Abstract

The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe the draft genome of three NDM-1-producing isolates: Providencia rettgeri (CCBH11880), Enterobacter hormaechei subsp. oharae (CCBH10892) and Klebsiella pneumoniae (CCBH13327), isolated in Brazil. Besides blaNDM-1, resistance genes to aminoglycosides [aadA1, aadA2, aac(6')-Ib-cr] and quinolones (qnrA1, qnrB4) were observed which contributed to the multidrug resistance profile. The element ISAba125 was found associated to the blaNDM-1 gene in all strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Brasilien
  • Drug Resistance, Bacterial / genetics
  • Enterobacter / enzymology
  • Enterobacter / genetics*
  • Genome, Bacterial / genetics*
  • Humans
  • Klebsiella pneumoniae / enzymology
  • Klebsiella pneumoniae / genetics*
  • Molecular Sequence Data
  • Providencia / enzymology
  • Providencia / genetics*
  • Sequence Analysis, DNA
  • beta-Lactamases / genetics*

Substances

  • beta-Lactamases
  • beta-lactamase NDM-1

Associated data

  • GENBANK/JSBO00000000
  • GENBANK/JSEQ00000000
  • GENBANK/JSER00000000