Abstract
While tuberculosis (TB) typically causes respiratory disease in adults, the spectrum of disease is different in children, ranging from paucibacillary lymphadenitis or limited intrathoracic disease to severe disseminated disease. Diagnosing pediatric TB and monitoring treatment response is challenging, as collecting respiratory specimens is difficult in children and disease may be extrapulmonary. While basic principles of treatment are similar to adults, developmental differences in pharmacokinetics and pharmacodynamics require that drug dosages in children be adjusted for body weight and age.
© 2015 ASCPT.
MeSH terms
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Age Factors
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / adverse effects
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Antitubercular Agents / pharmacokinetics
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Antitubercular Agents / therapeutic use*
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Body Size
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Child
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Child, Preschool
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Comorbidity
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Dose-Response Relationship, Drug
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Drug Dosage Calculations
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Drug Monitoring
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Drug-Related Side Effects and Adverse Reactions / etiology
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Drug-Related Side Effects and Adverse Reactions / prevention & control
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Humans
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Infant
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Infant, Newborn
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Risk Assessment
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Risk Factors
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Treatment Outcome
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Tuberculosis / diagnosis
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Tuberculosis / drug therapy*
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Tuberculosis / metabolism
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Tuberculosis / microbiology
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Tuberculosis / transmission