•We discuss the recurrence of breast carcinoma presenting as postmenopausal vaginal bleeding in a patient on Tamoxifen therapy.•Case report illustrates widespread genital tract manifestation of recurrent disease at time of presentation and rapid disease progression.•Discusses the importance of maintaining broad differential in diagnosis of postmenopausal vaginal bleeding.
Keywords: Breast carcinoma; Endometrium; Metastases; Tamoxifen.