Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

Nat Commun. 2015 Jun 30:6:7486. doi: 10.1038/ncomms8486.

Abstract

Mammalian species have co-evolved with intestinal microbial communities that can shape development and adapt to environmental changes, including antibiotic perturbation or nutrient flux. In humans, especially children, microbiota disruption is common, yet the dynamic microbiome recovery from early-life antibiotics is still uncharacterized. Here we use a mouse model mimicking paediatric antibiotic use and find that therapeutic-dose pulsed antibiotic treatment (PAT) with a beta-lactam or macrolide alters both host and microbiota development. Early-life PAT accelerates total mass and bone growth, and causes progressive changes in gut microbiome diversity, population structure and metagenomic content, with microbiome effects dependent on the number of courses and class of antibiotic. Whereas control microbiota rapidly adapts to a change in diet, PAT slows the ecological progression, with delays lasting several months with previous macrolide exposure. This study identifies key markers of disturbance and recovery, which may help provide therapeutic targets for microbiota restoration following antibiotic treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging*
  • Amoxicillin / administration & dosage
  • Amoxicillin / pharmacology*
  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology*
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Energy Metabolism / physiology
  • Feces / chemistry
  • Female
  • Gene Expression Regulation / drug effects*
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Metagenomics
  • Mice
  • Mice, Inbred C57BL
  • Transcriptome
  • Tylosin / administration & dosage
  • Tylosin / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Amoxicillin
  • Tylosin