Which Patient Characteristics Among Cocaine Users with HIV Relate to Drug Use and Adherence Outcomes Following a Dual-Focused Intervention?

AIDS Behav. 2016 Mar;20(3):633-45. doi: 10.1007/s10461-015-1119-6.

Abstract

This is a secondary analysis of data from a randomized trial of dually-focused interventions for nonadherent HIV patients with cocaine use disorders (Ingersoll et al. in Drug Alcohol Depend 116(1-3):177-187, 2011). We examined the relationships among baseline demographic, psychological, psychiatric, and behavioral characteristics and 6-months post-study ART adherence, log viral load (VL), ASI Drug Composite Score, and days using cocaine. We used the SAS GLMSELECT procedure to build multivariate models of each post-study outcome. Post-study ART adherence was related to 2 psychological variables; while logVL was related to 2 drug-related behaviors. ASI Drug Composite score was related to 2 psychiatric disorders, 1 demographic, and 1 psychological variable; in contrast, days using cocaine related to 1 behavioral and 3 psychological variables. Analyses show clear, robust relationships among behavioral, psychological and psychiatric diagnosis factors with post-study ART adherence and cocaine use outcomes. Future ART adherence interventions for cocaine users should consider tailoring to these patient characteristics.

Keywords: ART adherence; Crack cocaine; Patient characteristics.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Anti-Retroviral Agents / therapeutic use*
  • Cocaine-Related Disorders / epidemiology*
  • Cocaine-Related Disorders / psychology
  • Cocaine-Related Disorders / therapy
  • Crack Cocaine / administration & dosage
  • Crack Cocaine / adverse effects*
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • HIV Infections / psychology
  • Humans
  • Male
  • Medication Adherence / statistics & numerical data*
  • Middle Aged
  • Randomized Controlled Trials as Topic
  • Socioeconomic Factors
  • Treatment Outcome

Substances

  • Anti-Retroviral Agents
  • Crack Cocaine