Abstract
Group 2 innate lymphoid cells (ILC2s) produce high levels of IL-5 and IL-13, both of which are important pathogenic mediators in eosinophilic esophagitis (EoE). ILC2s have not been previously described in EoE. Our study demonstrates the novel finding that ILC2s are increased in esophageal biopsies from EoE patients with active disease compared with inactive EoE and non-diseased controls, implicating these cells in EoE pathogenesis.
Publication types
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Letter
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Antigens, CD / genetics
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Antigens, CD / immunology
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Biopsy
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Child
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Child, Preschool
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Cytokines / immunology*
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Cytokines / pharmacology
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Eosinophilic Esophagitis / genetics
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Eosinophilic Esophagitis / immunology*
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Eosinophilic Esophagitis / pathology
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Eosinophils / immunology*
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Eosinophils / pathology
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Esophagus / immunology*
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Esophagus / pathology
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Female
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Gene Expression Regulation
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Humans
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Immunity, Innate
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Immunophenotyping
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Infant
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Interleukin-13 / genetics
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Interleukin-13 / immunology
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Interleukin-33 / immunology*
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Interleukin-33 / pharmacology
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Interleukin-5 / genetics
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Interleukin-5 / immunology
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Lymphocyte Count
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Lymphocyte Subsets / drug effects
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Lymphocyte Subsets / immunology*
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Lymphocyte Subsets / pathology
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Primary Cell Culture
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Receptors, Immunologic / genetics
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Receptors, Immunologic / immunology
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Receptors, Prostaglandin / genetics
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Receptors, Prostaglandin / immunology
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Signal Transduction
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Thymic Stromal Lymphopoietin
Substances
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Antigens, CD
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Cytokines
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IL33 protein, human
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IL5 protein, human
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Interleukin-13
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Interleukin-33
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Interleukin-5
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Receptors, Immunologic
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Receptors, Prostaglandin
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prostaglandin D2 receptor
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Thymic Stromal Lymphopoietin