Aim: A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation.
Patients & methods: A PPK model was developed from 36 patients by a one-compartment model with first-order elimination.
Results: The typical value of clearance and volume of distribution were 11.0 l/h and 42.4 l, respectively. Clearance decreased by 15% and area under the concentration-time curves (AUCs) increased with GSTA1 variants compared with wild-type (both p < 0.05). Subtherapeutic AUCs were seen only in wild-type patients.
Conclusion: To our knowledge, this is the first PPK study to suggest that GSTA1 polymorphisms in adults are associated with busulfan PK.
Keywords: GSTA1; alloHSCT; allogeneic hematopoietic stem cell transplantation; busulfan; clinical outcomes; genetic polymorphisms; glutathione s-transferase a1; population pharmacokinetics.