Crawling with Virus: Translational Insights from a Neonatal Mouse Model on the Pathogenesis of Respiratory Syncytial Virus in Infants

Dahui You; Jordy Saravia; David Siefker; Bishwas Shrestha; Stephania A Cormier

doi:10.1128/JVI.01026-15

Crawling with Virus: Translational Insights from a Neonatal Mouse Model on the Pathogenesis of Respiratory Syncytial Virus in Infants

J Virol. 2015 Oct 7;90(1):2-4. doi: 10.1128/JVI.01026-15. Print 2016 Jan 1.

Authors

Dahui You¹, Jordy Saravia¹, David Siefker¹, Bishwas Shrestha¹, Stephania A Cormier²

Affiliations

¹ Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee, USA.
² Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA Children's Foundation Research Institute at Le Bonheur Children's Hospital, Memphis, Tennessee, USA [email protected].

Abstract

The infant immune response to respiratory syncytial virus (RSV) remains incompletely understood. Here we review the use of a neonatal mouse model of RSV infection to mimic severe infection in human infants. We describe numerous age-specific responses, organized by cell type, observed in RSV-infected neonatal mice and draw comparisons (when possible) to human infants.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Animals, Newborn
Disease Models, Animal*
Host-Pathogen Interactions*
Humans
Mice
Respiratory Syncytial Virus Infections / pathology*
Respiratory Syncytial Virus Infections / virology*
Respiratory Syncytial Viruses / physiology*

Abstract

Publication types

MeSH terms

Grants and funding