A rapid qPCR method to investigate the circulation of the yeast Wickerhamomyces anomalus in humans

New Microbiol. 2015 Oct;38(4):577-81. Epub 2015 Oct 20.

Abstract

The yeast Wickerhamomyces anomalus has been proposed for many biotechnological applications in the food industry. However, a number of opportunistic pathogenic strains have been reported as causative agents of nosocomial fungemia. Recognition of potentially pathogenic isolates is an important challenge for the future commercialization of this yeast. The isolation of W. anomalus from different matrices and, recently, from mosquitoes, requires further investigations into its circulation in humans. Here we present a qPCR protocol for the detection of W. anomalus in human blood samples and the results of a screening of 525 donors, including different classes of patients and healthy people.

Keywords: Wickerhamomyces anomalus; fungemia; mosquito vectors; opportunistic pathogen; qPCR.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood / microbiology*
  • Humans
  • Mycoses / blood
  • Mycoses / microbiology*
  • Real-Time Polymerase Chain Reaction / methods*
  • Saccharomycetales / classification
  • Saccharomycetales / genetics
  • Saccharomycetales / isolation & purification*