The SIN1-PH Domain Connects mTORC2 to PI3K

Hai-Xin Yuan; Kun-Liang Guan

doi:10.1158/2159-8290.CD-15-1125

The SIN1-PH Domain Connects mTORC2 to PI3K

Cancer Discov. 2015 Nov;5(11):1127-9. doi: 10.1158/2159-8290.CD-15-1125.

Authors

Hai-Xin Yuan¹, Kun-Liang Guan²

Affiliations

¹ Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
² Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, California. [email protected].

Abstract

The mTOR complex 2, mTORC2, is a critical downstream effector of PI3K that stimulates AGC kinase members, including AKT, PKC, and SGK. Liu and colleagues reported that the pleckstrin homology domain of SIN1, an essential component of mTORC2, directly binds the PI3K product PtdIns(3,4,5)P3 to promote mTORC2 kinase activation and membrane localization, thereby revealing a mechanistic link between PI3K and mTORC2. Cancer Discov; 5(11); 1127-9. ©2015 AACR.See related article by Liu and colleagues, p. 1194.

Publication types

News
Research Support, N.I.H., Extramural

MeSH terms

Adaptor Proteins, Signal Transducing / chemistry
Adaptor Proteins, Signal Transducing / metabolism*
Humans
Mechanistic Target of Rapamycin Complex 2
Multiprotein Complexes / metabolism*
Phosphatidylinositol 3-Kinases / metabolism*
Protein Binding
Protein Interaction Domains and Motifs*
Signal Transduction
TOR Serine-Threonine Kinases / metabolism*

Substances

Adaptor Proteins, Signal Transducing
MAPKAP1 protein, human
Multiprotein Complexes
Mechanistic Target of Rapamycin Complex 2
TOR Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

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