Efficient and synergetic DNA delivery with pyridinium amphiphiles-gold nanoparticle composite systems having different packing parameters

Adrian Kizewski; Marc A Ilies

doi:10.1039/c5cc05760d

Efficient and synergetic DNA delivery with pyridinium amphiphiles-gold nanoparticle composite systems having different packing parameters

Chem Commun (Camb). 2016 Jan 4;52(1):60-3. doi: 10.1039/c5cc05760d.

Authors

Adrian Kizewski¹, Marc A Ilies²

Affiliations

¹ College of Science and Technology, Temple University, 1803 N Broad Street, Philadelphia, PA-19122, USA.
² Department of Pharmaceutical Sciences and Moulder Center of Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA-19140, USA. [email protected] and Temple Materials Institute, 1803 N Broad Street, Philadelphia, PA-19122, USA.

PMID: 26553432
DOI: 10.1039/c5cc05760d

Abstract

Mixtures of highly curved pyridinium-decorated Au nanoparticles and standard pyridinium cationic lipids efficiently and synergetically transfected DNA in vitro, while displaying an excellent cytotoxic profile.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cell Line, Tumor
DNA / administration & dosage*
DNA / genetics
Gold / chemistry*
Humans
Nanoparticles / chemistry*
Pyridinium Compounds / chemistry*
Surface-Active Agents / chemistry*
Transfection*

Substances

Pyridinium Compounds
Surface-Active Agents
Gold
DNA