Real-World Executive Functions in Adults with Autism Spectrum Disorder: Profiles of Impairment and Associations with Adaptive Functioning and Co-morbid Anxiety and Depression

J Autism Dev Disord. 2016 Mar;46(3):1071-83. doi: 10.1007/s10803-015-2655-7.

Abstract

Although executive functioning (EF) difficulties are well documented among children and adolescents with autism spectrum disorder (ASD), little is known about real-world measures of EF among adults with ASD. Therefore, this study examined parent-reported real-world EF problems among 35 adults with ASD without intellectual disability and their correlations with adaptive functioning and co-morbid anxiety and depression symptomatology. A variable EF profile was found with prominent deficits occurring in flexibility and metacognition. Flexibility problems were associated with anxiety-related symptoms while metacognition difficulties were associated with depression symptoms and impaired adaptive functioning (though the metacognition-adaptive functioning relationship was moderated by ADHD symptoms). These persistent EF problems are predictors of broader functioning and therefore remain an important treatment target among adults with ASD.

Keywords: Adaptive functioning; Adult; Anxiety; Autism; Depression; Executive function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Adaptation, Psychological* / physiology
  • Adolescent
  • Adult
  • Anxiety / diagnosis
  • Anxiety / epidemiology
  • Anxiety / psychology*
  • Autism Spectrum Disorder / diagnosis
  • Autism Spectrum Disorder / epidemiology
  • Autism Spectrum Disorder / psychology*
  • Comorbidity
  • Depression / diagnosis
  • Depression / epidemiology
  • Depression / psychology*
  • Executive Function* / physiology
  • Female
  • Humans
  • Male
  • Neuropsychological Tests
  • Young Adult